Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia

Inclusion Criteria

• •1. Age 20-65 year-old.
• •2. Fulfill DSM-IV-TR diagnosis of schizophrenia.
• •3. Be treated with an antipsychotic agent for at least 6 months or at a stable dose for at least 3 months.
• •4. Patients with folate deficiency or insufficiency, and PANSS score at least 60 or more in the first phase screening.
• •Folate deficiency and insufficiency (low folate level) are defined as serum folate \< 6.8 nmol/L (3 ng/mL) and \<= 13.5 nmol/L (6 ng/mL), respectively.