Adjuvant Ovarian Suppression Plus Aromatase Inhibitor or Tamoxifen in Young Women

Exclusion Criteria

• •1. Pregnant or lactating women or women of childbearing potential reject contraceptive measures;
• •2. History of organ transplantation (including autologous bone marrow transplantation and peripheral stem cell transplantation);
• •3. Concurrent malignancies or history of non-breast malignancies within the 5 years prior to study entry, except for curatively treated basal cell and squamous cell carcinomas of the skin, carcinoma in situ of the cervix; peripheral nervous system disorders caused by diseases or history of obvious mental and central nervous system disorders;
• •4. Prior use of neo-adjuvant chemotherapy after a definite diagnosis;
• •5. Nervous system disorders caused by diseases or obvious mental disorder, which would affect patients right to consent and compliance, or make patients in critical condition;
• •6. Serious hepatopathy (e.g., cirrhosis, etc.), nephropathy, respiratory illness, digestive illness or poorly controlled diabetes;
• •7. Cardiac illness with obvious abnormal EKG or clinical symptoms, namely congestive heart failure, coronary atherosclerotic heart disease with obvious symptoms, arrhythmia difficult to control by drugs, or history of myocardial infarction within the 12 months prior to study entry or class III/IV of cardiac function;
• •8. Concurrent treatment in another investigational trial;
• •9. Sensitivity or contraindication to any of the study medications.