Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Laval University
With
Canadian Institutes of Health Research (CIHR)
The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle angiogenesis. Mild to severe COPD patients and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins and microRNAs of signaling intramuscular pathways involved in angiogenesis will be measured in the quadriceps.
Age
50–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
COPD (FEV1/FVC \< 0.70)
Healthy subjects: no evidence of airways obstruction (FEV1/FVC \> 0.70 and FEV1 \> 0.80 predicted)
Smoking history \> 10 pack-years
Ex-smoker \>6 months
You may not be if
Chronic hypoxemia and/or hypercapnia (PaO2 \< 60 mmHg or SpO2 \< 88% at rest and/or PaCO2 \> 45 mmHg)
Recent exacerbation or oral corticosteroids (\< 2 months)
Recent cancer (\< 3 years)
Diabetes
Myopathy, neuromuscular, neurological or articular diseases
Kidney disease
Other respiratory diseases
Unstable cardiac disease
Physical activity score \> 9 in the Voorips questionnaire
BMI \> 30
Clareo Health | Expression of miR-204 and Consequences on Capillarization in Limb Muscles of Patients With COPD
