Virtual Reality and Robot Assisted Gait Training in Patients With Multiple Sclerosis

Exclusion Criteria

• •patients with disease recurrence that has worsened significantly during the 8 weeks before recruitment;
• •changes in pharmacological therapy that could modify the disease course in the previous 3 months before recruitment;
• •changes in pharmacological therapy for fatigue treatment in the previous 3 months before recruitment
• •medications altering central nervous system (excitability (e.g., antiepileptics, neuroleptics, benzodiazepines or antidepressants) or with presumed effects on central nervous system plasticity (e.g., dopamine, fluoxetine or D-amphetamine);
• •other neurological or orthopedic conditions involving the lower limbs (musculoskeletal diseases, severe osteoarthritis, peripheral neuropathy, joint replacement);
• •cardiovascular co-morbidity (recent myocardial infarction, heart failure, uncontrolled hypertension, orthostatic hypotension).