Clareo Health | Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver
Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver
Bilirubin \< 25 mmol/L, AST \< 5x ULN, ALT \< 5 x ULN, ALP \< 5 x ULN, TP \> 60%, proteinuria from 24H \< 1 g
Creatinine clearance \> 50 mL/min according to MDRD formula (Appendix 4)
Patient affiliated to a social security scheme
Patient information and signature of the informed consent
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Contraindications specific to the installation of a KTHIA: thrombosis of the hepatic artery, arterial vascular anatomy may compromise a secondary hepatic resection.
Patient immediately eligible for a curative therapy (surgical and/or percutaneous) after discussion in CPR
Following alterations in the 6 months prior to inclusion: myocardial infarction, angina, severe/unstable angina, coronary artery bypass surgery, congestive heart failure NYHA class II, III or IV, stroke or transient ischemic attack
Hypertension not controlled by medical treatment (SBP \> 140 mmHg and/or DBP\> 90 mmHg with blood pressure taken according to the diagram of the HAS)
A history of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess or active gastrointestinal bleeding in the 6 months preceding the start of treatment
Progressive gastroduodenal ulcer, wound or fractured bone
Abdominal or major extra-abdominal surgery (except diagnostic biopsy) or irradiation in the 4 weeks before starting the treatment
Transplant patients, HIV positive or other immune deficiency syndromes
Any progressive pathology not balanced over the past 6 months: hepatic failure, renal failure, respiratory failure
Peripheral neuropathy \> 1
Patient with interstitial pneumonitis or pulmonary fibrosis
History of chronic diarrhea or inflammatory disease of the colon or rectum, or unresolved occlusion or sub-occlusion in symptomatic treatment
History of malignant pathologies during the past 5 years except basocellular skin carcinoma considered in complete remission or in situ cervical carcinoma, properly treated
Patient already included in another clinical trial with an experimental molecule
Any known specific contraindication or allergy or hypersensitivity to the drugs used in the study (cf RCP Appendix 7)
Known deficit in DPD
QT/QTc range \> 450 msec for men and \> 470 msec for women
K+ \< LNL, Mg2+ \< LNL, Ca2+ \< LNL
Lack of effective contraception in patients (men and/or women) of childbearing age, pregnant or breastfeeding women, women of childbearing age not having had a pregnancy test
Persons deprived of liberty or under supervision
Impossibility of undergoing medical monitoring during the trial for geographic, social or psychological reasons
