Finding studies
Finding studies
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Lead
Enterome
With
350 Crohn's disease patients will be included in the study, targeting 300 evaluable patients. An interim analysis will be performed after 50% of the evaluable patients are recruited. The primary objective is to evaluate the relation between non-invasive biomarkers (host immunological variables and metagenomic analysis in stools) and AIEC detection in biopsies taken during an endoscopy, in order to develop a predictive algorithm of AIEC carriage. The secondary objectives are: * Validation of the AIEC detection algorithm using qPCR technology. * Assessment of the correlation between the presence of AIEC and the endoscopic and clinical evaluations of the disease (CDEIS, SES-CD, Harvey-Bradshaw Index and Crohn's Disease Activity Index). * Development and validation of a non-invasive qPCR based diagnostic of Mucosal Healing in CD patients. * Collection of biological samples associated with all clinical and biological data from CD patients.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
