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Impact of IV Acetaminophen on Post-operative Pain After Laparoscopic Appendectomy for Perforated Appendicitis: A Prospective Randomized Trial
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis. The investigators hypothesize that the use of intravenous (IV) acetaminophen in addition to IV ketorolac with narcotic pain pump will decrease time to transition off patient/nurse controlled analgesia (PCA) to oral pain medications.
To assess pain control, patient and family perception of pain control, time to return of bowel function defined as passage of first flatus (in days), doses of anti-emetic medications, doses of narcotic pain medications, time to toleration of regular diet (in days), narcotic associated adverse effects (nausea, emesis, respiratory depression, constipation), length of stay, and overall hospital cost in admission. Post-hospitalization the investigators will assess complications including number and reasons for emergency visits and abscess formation, length of post-hospitalization analgesic use, length of post-hospitalization narcotic use, and time to return to school.
Age
2 - 17 years
Sex
ALL
Healthy Volunteers
No
Children's Mercy Hospital
Kansas City, Missouri, United States
Start Date
June 1, 2014
Primary Completion Date
June 1, 2016
Completion Date
August 1, 2016
Last Updated
January 12, 2021
90
ACTUAL participants
IV tylenol
DRUG
No IV tylenol
DRUG
Ketorolac
DRUG
Lead Sponsor
Children's Mercy Hospital Kansas City
Data Source & Attribution
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