Finding studies
Finding studies
Take this into the appointment.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Lead
University of Washington
With
PRIMARY OBJECTIVES: I. To determine the maximally tolerated dose (MTD) of nortriptyline hydrochloride (nortriptyline) combined with weekly paclitaxel (PC). SECONDARY OBJECTIVES: I. To assess the overall response rate (ORR) to nortriptyline combined with PC. II. To assess progression free survival (PFS) and overall survival (OS). OUTLINE: This is a dose-escalation study of nortriptyline hydrochloride. Patients receive paclitaxel intravenously (IV) on days 1, 8, and 15. Patients also receive nortriptyline hydrochloride orally (PO) once daily (QD) on days 1-7, twice daily (BID) on days 8-14, and thrice daily (TID) on days 15-28 of course 1 and TID on days 1-28 of subsequent courses. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 28 days and every 3 months for 2 years.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted