Feasibility Study on LITT for Newly Diagnosed Glioblastoma

Exclusion Criteria

• •1. Seizures occurrence or the requirement of escalation (or addition) of anti-epileptic drugs
• •2. Symptoms due to mass effect of the tumor including high intracranial pressure, marked edema or ≥5mm midline shift significant
• •3. Uncontrolled cardiovascular conditions of hypertension (systolic \>180 mm Hg), angina pectoris, or cardiac dysrhythmia; or recent history of intracranial hemorrhage
• •4. Serious infection, immunosuppression or concurrent medical condition (chronic or acute in nature) that may prevent safe participation or ability to meet follow-up requirements
• •5. Pregnancy, or planning to become pregnant
• •6. Patients whose physical dimensions cannot be accommodated in the MRI scanner or patients with contraindications to MRI imaging such as pacemakers, non-compatible aneurysm clips, shrapnel and other internal ferromagnetic objects
• •7. Patients with multiple or multifocal GBM