A Study to Compare the Oral Bioavailability of Single Doses of Three Vapendavir Drug Formulations in Healthy Volunteers

Exclusion Criteria

• •1. Positive results at screening for hepatitis B, hepatitis C, or HIV;
• •2. No use of tobacco products, as well as electronic cigarettes, within 14 days of Study Day 1 or unwilling to abstain during study participation;
• •3. A medical history or clinical evidence of any clinical condition that may, in the opinion of the Investigator or Medical Monitor, impact on the subject's ability to participate in the study, or on the study results;
• •4. Current or recent respiratory or other infection within 14 days of screening;
• •5. Presence or history of significant allergy requiring treatment;
• •6. Clinically significant abnormalities on ECG;
• •7. Vital signs representing abnormal systolic blood pressure and/or abnormal diastolic blood pressure;
• •8. Safety laboratory abnormalities at screening or Study Day 0 which are clinically significant;
• •9. Subject has a history of drug abuse or alcohol abuse in the past 2 years or current evidence of such abuse or addiction;
• •10. A positive urine drug screen test at screening or admission to the study facility;
• •11. A positive breathalyzer for alcohol at screening or admission to the study facility;
• •12. A positive pregnancy test at screening or admission to the study facility;
• •13. Abstinence from alcohol must be employed from 72 hours before Study Day 1 and throughout the duration of study participation;
• •14. Use of chronic prescription medications within 90 days, with the exception of hormonal contraceptives (or contraceptive device containing hormonal contraceptive) being taken by female subjects within 14 days, or over-the-counter (OTC) medications, including vitamin, herbal, and mineral supplements, within the 7 days prior to Study Day 1 and throughout study participation;
• •15. Received an investigational drug or investigational vaccine within 30 days, or use of an investigational medical device within 30 days prior to Study Day 1;
• •16. Any prior use of vapendavir or inclusion in a previous vapendavir investigational study or ongoing participation in a vapendavir investigational study;
• •17. Donation or loss of whole blood within 60 days or plasma within 14 days of Study Day 1 or anytime from screening to 30 days after completion of the study.