Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia

Inclusion Criteria

• •Patients with critical lower limb ischemia, with resting pain wich can't be adequately managed by opioid analgetics and/or foot ulcers or necrosis, with II-4, III-5 и IV-6 stages of chronic arterial failure according to Rutherford's classification
• •Ankle-brachial index less than 0.4 and/or ТСрО2 less than 30 mm Hg
• •Patients with lower limbs' arteries lesions revealed by angiography uneffectiveness or impossibility of limb's revascularisation or patient's refusal of the procedure
• •Patient is familiar with Participant information sheet
• •Patient signed informed consent form
• •Contraindications for local anesthesia or history of allergy for local anesthetics
• •Systemic glucocorticoid and/or immunosuppressant therapy
• •Any condition that might limit compliance (dementia, mental disorders, narcotic drug or alcohol abuse etc.)
• •Participation in other clinical trials (or administration of investigational drugs) during 3 months prior inclusion
• •Patients with malignant tumors including postoperative period, patients receiving chemotherapy and/or radiotherapy
• •Clinically significant abnormalities in results of laboratory tests
• •Patient received anticoagulants at least 12 hours prior the liposuction
• •Medical history of heterotopic ossifications
• •Patients prescribed for glycoprotein inhibitors treatment