Age

18–70

Sex

FEMALE

Healthy volunteers

Not accepted

Patients receiving IP chemotherapy and therefore meeting the following criteria:
Primary epithelial ovarian carcinoma FIGO stage III;
Optimal or complete primary debulking (tumor rests ≤ 1cm;
WHO 0 - 2;
Adequate hematological function: WBC ≥ 3. 106/L en Platelets ≥ 100. 106/L,
Adequate renal function (Creatinine clearance \>60 ml/min (Cockcroft))
Adequate liver function tests (bilirubin and/or transaminases \<1.25 UNL)

A potential subject who meets any of the following criteria will be excluded from participation in this study (according to the standard IP chemotherapy):
Intestinal stoma proximal to the flexura lienalis;
Postoperative sepsis after primary debulking;
Haemoglobin \< 6.0 mMol/L
Extended intraperitoneal adhesions;
Neurotoxicity grade\>1;
Previous chemotherapy for ovarian carcinoma;
Symptomatic hearing loss;
Age \>70 years.

Intra-peritoneal Chemotherapy in Ovarian Cancer