Management of Tobacco Treatment Intervention in Reducing Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes

You may be eligible if

• Eligible patients will have a new diagnosis of lung cancer and have sought a surgical consult relating to this diagnosis
• Surgery must be scheduled no sooner than 10 days after randomization and no more than twelve weeks after randomization
• Have smoked daily or nearly every day in the previous 6 months up to the date of surgical consult AND have smoked at least one puff in the previous 7 days
• Motivated to stop smoking, as indicated by a score of 6 or above on the Contemplation Ladder
• Within the 30 days before registration, no use of: 1) any pharmacologic treatment for smoking cessation, including bupropion or nicotine replacement therapy; 2) any nicotine delivery system (i.e., e-cigarettes and vape products); or 3) be enrolled in any formal behavioral treatment program for tobacco dependence as determined by patient report
• No allergies to and not currently using varenicline
• No suicidal thoughts as indicated by a positive (1+) response to the PHQ9
• No active untreated clinically significant psychiatric condition (psychosis, bipolar disorder, or depression)
• Negative pregnancy test (serum or urine) done =\< 7 days prior to registration, for women of childbearing potential only
• \* A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
• No unstable angina, myocardial infarction, or coronary angioplasty within the past 3 months or an untreated cardiac dysrhythmia
• No history of seizures
• No unstable neurologic, hepatic, renal, cardiovascular, lymphatic, or metabolic disease
• Not currently on renal dialysis or has a history of significant renal impairment
• No recent history (=\< 90 days) of substance abuse (outside of tobacco) defined by National Institute on Alcohol Abuse and Alcoholism (NIAAA) as:
• * If male, drinking \> 14 alcoholic beverages per week for past 1 month
• * If female, drinking \> 7 alcoholic beverages per week for past 1 month
• * Use of cocaine, heroin, club drugs (i.e., 3,4-methylenedioxymethamphetamine (MDMA)/"ecstasy"), methamphetamine, or hallucinogens (e.g., lysergic acid diethylamide \[LSD\]) at any time during the past 1 month
• * Use of marijuana on a weekly basis for the past 1 month
• Patients must be able to complete study questionnaires in English
• No other household member or relative participating in the study
• No known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder study adherence
• Calculated creatinine clearance \>= 30 mL/min \* For females, use 85% of calculated creatinine clearance (CrCl) value