Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia

PRIMARY OBJECTIVES: I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia. SECONDARY OBJECTIVES: I. To establish a microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis. OUTLINE: Patients undergo collection of blood samples before and during the episode of febrile neutropenia for up to 6 weeks.