Study of Abemaciclib in Dedifferentiated Liposarcoma

Inclusion Criteria

• •A diagnosis of dedifferentiated liposarcoma confirmed at MSKCC.
• •Metastatic and/or locally advanced or locally recurrent disease that is not surgically resectable.
• •All patients must have measurable disease as defined by RECIST 1.1. Patients must also have evidence of disease progression by RECIST 1.1 within 6 months of first dose of study drug.
• •Any number of prior therapies (including none) is permitted. The last dose of systemic therapy (include targeted therapies) must have been given at least 2 4 weeks prior to initiation of therapy. Patients receiving BCNU or mitomycin C must have received their last dose of such therapy at least 6 weeks prior to initiation of therapy.
• •Patients with brain metastasis that have been treated with definitive surgery or radiation and have been clinically stable for 3 months are eligible.
• •Age ≥ 18 years.
• •ECOG performance status 0 or 1
• •Adequate organ and marrow function as defined below (ULN indicates institutional upper limit of normal):
• •Absolute neutrophil count ≥ 1.510\^9/L
• •Hemoglobin ≥ 8.0 g/dL
• •WBC ≥ 3.0 x 10\^9/L
• •Platelets ≥ 100 x 10\^9/L
• •Total bilirubin ≤ 1.5 x ULN except for patients with known Gilbert syndrome
• •AST(SGOT)/ALT(SGPT) ≤ 3 x institutional ULN
• •Creatinine ≤ 1.5 x ULN or Creatinine Clearance \> 50 mL/min (calculated by Cockcroft-Gault method)
• •Patients must not have current evidence of another malignancy that requires treatment.
• •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence). Women must not breast feed while on study.
• •Ability to understand and the willingness to sign a written informed consent document.
• •Ability to swallow capsules