Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Toulouse
Age
60–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
For all subjects :
Capacities visual, auditory (authorized devices) and oral or written expression sufficient for the proper performance of tests
Obtain informed written consent of the subject
Patients with AD :
Outpatient accompanied by a "helping"
No parenchymal lesions allowing isolation explain the symptoms on brain MRI (T1 and T2) carried more than 6 months prior to enrollment in the study. Patients with more than three hyperintense white matter or visible lacunar infarction or T2 FLAIR will not be included in the study.
probable Alzheimer's disease diagnosis par with international standards
Illness in a mild stage (CDR 1, 24 ≥ Mini-Mental State Examination (MMSE)\> 18)
activity of daily living (ADL) 4 items\> 1/4
Patients with Alzheimer's disease at a pre-dementia stage:
Alzheimer's Diagnosis pre-dementia based on the search criteria
Illness in a mild stage (CDR 0.5, 30 ≥ MMSE ≥ 25)
ADL items ≤ 4 1/4
Control subjects :
30 ≥ MMSE ≥ 27
perfect autonomy in daily living (IADL = 0, CDR = 0)
Neuropsychological evaluation not highlighting of impaired cognitive performance with focus on memory performance
No parenchymal lesions on brain MRI.
Lack of family history (first degree) of Alzheimer's disease
You may not be if
Subjects with a contra-indication to MRI (carrying a pacemaker or cardiac defibrillator, implanted a material activated by an electrical, magnetic or mechanical carriers hemostatic clips intracerebral aneurysms or carotid artery , holders of orthopedic implants, claustrophobia)
Subjects with clinically significant gastrointestinal, renal, hepatic, endocrine, or cardiovascular
Subjects with a psychiatric disorder or progressive neurological
French Language level insufficient to be appropriately involved in neurophysiological evaluation
less than 5 years Education (insufficient understanding level to participate in the study)
Administrative problems: unable to give informed about information, not covered by a social security system
Hypersensitivity to the active substance or to any of the excipients
unbalanced diabetes mellitus
Subjects treated by a non-steroidal anti-inflammatory
