A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes

Exclusion Criteria

• •Subjects participate in another intervention research or study using imaging.
• •Contra-indication for undergoing18F-NaF PET/CT scan (claustrophobia, pregnancy, breastfeeding).
• •Subject underwent amputation of the lower extremities (above the knee).
• •Using vitamin K antagonists.
• •Known coagulation problems (history of Venous Thrombo Embolism).
• •Using vitamin supplements that contain vitamin K, or unwilling to stop two weeks before randomisation.
• •A mean vitamin K2 intake ≥120 microgram/day measured with a questionnaire.
• •Natto or goose liver consumers.
• •Low kidney function (eGFR\<30).