A Study Evaluating the Efficacy of a Single Injection Autologous Adipose Derived Mesenchymal Stromal Cells in Patients With Knee Osteoarthritis

Exclusion Criteria

• •Previous treatments acting on cartilage or bone metabolism
• •Received intra-articular injection of corticosteroids, platelet rich plasma or hyaluronic acid within the previous 6 months,
• •Significant trauma or surgery to the index knee within the last year or arthroscopy of the index knee within 12 months of screening.
• •Kellgren-Lawrence Grade 1 or 4 in the index knee on any incidences.
• •Osteoarthritis causing significant pain in any joint other than the identified knee, i.e., pain in hip, or contralateral knee (≥ 20 mm pain) as confirmed by a separate VAS at baseline for any other painful joint concerned
• •History of joint replacement of the knee or hip within the previous 12 months