CKD-396 Drug-drug Interaction Study(B) (CKD-396 DDI(B) P1)

Exclusion Criteria

• •1. A person who had a history or symptoms of clinically aware of blood, kidney, internal secretion, gastrointestinal, urinary system, cardiovascular, liver, mental, nercous, or allergic(except subclinical seasonal allergies that is not treated at injecion) desease.
• •2. Who had a gistory of gastrointestinal related disease which can be affected the drug absorption (esophageal achalasia, esophagostenosis, esophageal disease, or Crohn's disease) or surgeries (except a simple appendectomy or herniotomy).
• •3. Who had following results after examination(a. ALT or AST \> twice higher than normal value).
• •4. Who constantly intake 210 g/week of alcohol within 6 months of the screening. (a cup of beer (5%) (250 mL) = 10 g, a shot of soju (20%) (50mL) = 8 g, a glass of wine (!2%) (125 mL) = 12g).
• •5. Who participated other clinical test or took testing bioequivalence drugs in 3 months before the first clinical drug trial.
• •6. Whose blood pressure ≤ 100 or ≥150(systolic blood pressure) or \< 60 or ≥ 100(diastolic blood pressure).
• •7. Who had a medical history of alcohol and drug abuses.
• •8. Who had taken a drug that has a control of metabolic rate (activatioh or inhibithion) in 30 days before the first taking of clinical testing durg.
• •9. WHo smokes more than 20 eigarettes per day.
• •10. Who took prescribed drugs or over-the-conuter durgs in 10 days before taking of very first clinical testing drug.
• •11. Who participated in whole blood donation in 2 months before the first taking of clinical testing drugs or platelet donations in 1 month before the first taking to clinical testing drugs.
• •12. Who has a potent to increase a danger by participating in the clinical trials or sho can interrupt interpretin test results by having serious or chronic medical and mental status or having issues in results of the screening examination.
• •13. Who has a histroy of an extreme sensitivity of drugs that contain the ingredients of Sitagliptin or thiazolidinediones drugs or drugs that contain Rosiglitazone or dugs that have similar effect a Rosiglitazone(Pioglitazone).
• •14. Who has a serious heart failure or a congestive heart failure that must be drug-treated.
• •15. A patient with hepatopathy.
• •16. A patient with wevere nephropathy.
• •17. Who has diabetic ketoacidosis or a diaetic coma, or type 1 diabetes, or has history of acute metablic acidosis or ketoacidosis.
• •18. A patient with serious infectious disease or severe injuries before and after a surgery.
• •19. Who has Galactose intolerance, LAPP lactose intolerance, glucose-galactose malabsorption or genetic disorders.
• •20. Test subjects who is not willing or unable to comply with guidelines described in this protocol.
• •21. A person who is not determined unsuitable to participate in this test by the researchers.