Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Virginia
With
National Institutes of Health (NIH)
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subjects should be at their clinical baseline on the day of imaging
Subjects must be clinically stable in order to participate in the study
Smoking history \>10 pack years
Subjects must not be currently taking Advair or have taken it within 4 weeks prior to screening
No subject will be withdrawn from Advair to participate in this study
The subjects with COPD will be categorized according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPD severity classification:
Class 1: forced expiratory volume at one second (FEV1)/forced vital capacity (FVC) \< 70 and FEV1 \> 80% predicted;
Class 2: FEV1/FVC \< 70 and 50% \< FEV1 \< 80% predicted;
Class 3: FEV1/FVC \< 70 and 30% \< FEV1 \< 50% predicted;
Class 4: FEV1/FVC \< 70 and FEV1 \< 30% predicted
You may not be if
Continuous oxygen use at home
Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging
FEV1 percent predicted less than 25%
Pregnancy or lactation
Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.
Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches.
History of congenital cardiac disease, chronic renal failure, or cirrhosis.
Inability to understand simple instructions or to hold still for approximately 10 seconds.
History of respiratory infection within 2 weeks prior to the MR scan
History of myocardial infarction (MI) , stroke and/or poorly controlled hypertension.
Known hypersensitivity to albuterol or any of its components, or levalbuterol
Glomerular filtration rate (GFR) \< 60 ml/min/1.73 m2 or known hypersensitivity to Gd-contrast agents based on a serum creatinine drawn within 30 days of the MRI
Acute kidney injury
History of paraproteinemia syndromes such as multiple myeloma
Hepatorenal syndrome
Liver transplant
Clareo Health | New Technology to Assess Treatment for Chronic Obstructive Pulmonary Disease (COPD)
