Finding studies
Finding studies
Take this into the appointment.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Lead
Olivia Newton-John Cancer Research Institute
With
Primary Objective \& Hypothesis (1) Objective: To evaluate the safety of intravenous CVA21 in combination with pembrolizumab in patients with advanced NSCLC. Hypothesis: Pembrolizumab in combination with intravenous CVA21 will be well tolerated in patients with advanced NSCLC. Secondary Objective \& Hypothesis (1) Objective: i. To evaluate the efficacy of intravenous CVA21 in inducing an immune cell rich tumour microenvironment in patients with a baseline biopsy demonstrating a tumour with an immune cell poor microenvironment. ii. To evaluate the efficacy of intravenous CVA21 in combination with pembrolizumab in patients with advanced NSCLC using irRECIST. iii. To evaluate the safety of intravenous CVA21 in combination with pembrolizumab. iv. To identify a safe and potentially effective dose for intravenous CVA21 in combination with intravenous pembrolizumab. v. To serially evaluate the presence of detectable virus and anti-viral antibodies in peripheral blood of the trial participants. Hypothesis: i. CVA21 will induce immune cell infiltration into tumors of patients that lack an immune cell rich micro-environment.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted