Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Brigham and Women's Hospital
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
History of asthma
History of nasal polyposis
History of at least one clinical reaction to oral aspirin or other nonselective COX inhibitor with features of both lower (cough, chest tightness, wheezing, dyspnea) and upper (rhinorrhea, sneezing, nasal obstruction, conjunctival itching and discharge) airway involvement
Stable asthma (post-bronchodilator FEV1 of ≥70%, no use of oral or systemic steroids for at least 1 month, and no hospitalizations or emergency room visits for asthma for the prior 6 months) at the time of entry into the study
Currently taking montelukast as part of standard asthma treatment for at least 4 weeks before the V1 visit
You may not be if
Pregnancy or current breastfeeding
History of bleeding diathesis or use of anticoagulant or antiplatelet drugs
History of thrombocytopenia \< 50 x 10\^9/L
Hypersensitivity to montelukast
Peptic ulcer disease
Unstable asthma (post-bronchodilator FEV1 of less than 70%, use of oral or systemic steroids for at least 1 month prior to visit 1, or hospitalizations or emergency room visits for asthma for the prior 6 months)
Use of zileuton (which can mask symptoms of aspirin-induced reaction) within 1 month prior to the V1 visit
Age under 18 or over 75 years
Current smoking
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