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TERMINATEDNA

To Evaluate the Efficacy of EEG-guided Magnetic Resonant Therapy in War Veterans With Posttraumatic Stress Disorder

A Pilot Study to Evaluate the Efficacy of EEG/ECG-guided Magnetic Resonant Therapy (MeRT) in War Veterans With Posttraumatic Stress Disorder (PTSD) at Tinker and MacDill Air Force Bases

NCT02824445•72nd Medical Group, Tinker Air Force Base

View on ClinicalTrials.gov

Summary

After 13 years of war, PTSD has become pervasive in service members. Traditionally it is evaluated by PTSD Checklist Military Version (PCL-M) and treated with cognitive processing therapy, prolonged exposure therapy and medication management with limited success. Repetitive Transcranial Magnetic Stimulation (TMS) has shown efficacy for improving individual cognitive function in the past decades, both in healthy population and in patients with depression. TMS has been approved by the FDA in treatment of major depressive disorder and migraine headaches. Magnetic EEG guided Resonant Treatment (MeRT) is a form of individualized TMS based on member's EEG/ECG input. Investigators propose to use MeRT to treat veterans with war-related PTSD, a syndrome that includes depressive and anxious symptoms; it is likely that MeRT (namely TMS) will be beneficial and comparable to or better than the current FDA approved methods for treating PTSD.

Eligibility

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Have diagnosis of combat-related PTSD by DSM-V criteria, diagnosed via clinical interview by psychologist or psychiatrist (note: combat pilots of remotely piloted aircraft are included)
•2. PCL-M score \> 45
•3. Age between 18 and 55 years (at day of informed consent)
•4. Willing and able to adhere to the treatment schedule and all required study visits.
•5. Must be clinically stable for at least 30 days on or off any PTSD medication before the trial treatment

Exclusion Criteria

•1. Individuals diagnosed by the Investigator with the following conditions (current unless otherwise stated):
•* History of open skull traumatic brain injury
•* History of clinically significant seizure disorder
•2. Individuals with a clinically defined neurological disorder including, but not limited to:
•* Any condition likely to be associated with increased intracranial pressure
•* Space occupying brain lesion
•* History of cerebrovascular accident
•* Cerebral aneurysm
•3. Abnormalities that indicate risk of seizure, i.e., focal or general slowing or spikes during EEG recording
•4. Any type of rTMS treatment within 3 months prior to the screening visit
+8 more criteria

Locations (1)

72d Medical Group

Oklahoma City, Oklahoma, United States

Key Dates

Start Date

May 1, 2015

Primary Completion Date

May 28, 2018

Completion Date

May 28, 2018

Last Updated

January 2, 2020

Enrollment

ACTUAL participants

Conditions

Post-Traumatic Stress Disorders

Interventions

individualized Transcranial Magnetic Stimulation

DEVICE

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ACTIVE_NOT_RECRUITINGNA

The Feasibility and Examination of the Effects of Floatation-based REST on a Community Sample With PTSD

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COMPLETEDPHASE1

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 2, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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To Evaluate the Efficacy of EEG-guided Magnetic Resonant Therapy in War Veterans With Posttraumatic Stress Disorder

Inclusion Criteria

Exclusion Criteria

Mental Health in Veterans and Families After Group Therapies

The Feasibility and Examination of the Effects of Floatation-based REST on a Community Sample With PTSD

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

Trauma Informed Guilt Reduction Therapy

Telemedicine Management of Chronic Insomnia

Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder