Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Bayer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subjects must have histologically confirmed, locally advanced or metastatic solid cancers of the following histological types:
1. predominantly epithelial (≥50% tumor component) pleural or peritoneal mesothelioma
2. epithelial ovarian cancer (fallopian tube and primary peritoneal cancers are eligible)
3. adenocarcinoma of the pancreas,
4. triple-negative adenocarcinoma of the breast
5. non-small-cell adenocarcinoma of the lung
6. gastric cancer (including gastro-esophageal junction)
7. colon cancer
8. cholangiocarcinoma
9. Thymic carcinoma
Subjects must have no standard therapy available, or have actively refused standard therapy
Subjects must provide samples of archival tumor tissue collected and submitted anytime during the study
Subjects must have a life expectancy of at least 12 weeks
Subjects must have ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1
Subjects must have adequate bone marrow, renal and hepatic function and coagulation
Subjects must have normal or clinically insignificant ECG at screening
Women of reproductive potential must have a negative serum pregnancy test obtained within 3 days before the start of anetumab ravtansine
Women of childbearing potential and fertile men must agree to use adequate contraception when sexually active. This applies from the time period between signing of the informed consent until at least 6 months after the last administration of the last study drug. Male patients with a female partner of childbearing potential must use a condom and ensure that an additional form of contraception is also used during treatment and until 6 months after last study drug administration.
You may not be if
Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study, except cervical carcinoma in situ, treated basal cell carcinoma, superficial noninvasive bladder tumors or any previous cancer curatively treated ≥ 3 years before the start of anetumab ravtansine
New or progressive brain or meningeal or spinal metastases
Corneal epitheliopathy or any eye disorder that may predispose the subjects to drug-induced corneal epitheliopathy, or may interfere with diagnosis of treatment-emergent corneal epitheliopathy at the ophthalmologist's or the investigator's discretion
History or current evidence of
* biliary cirrhosis
* malignant biliary obstruction unless the bile flow to the gastrointestinal tract is maintained by a fully operational biliary stent
* CTCAE (Common Terminology Criteria for Adverse Events) Grade ≥2 bleeding disorder within 4 weeks before the start of anetumab ravtansine
* uncontrolled cardiovascular disease or uncontrolled hypertension
* Long QT Syndrome
* HIV infection
* Hepatitis B or C infection
Had a major surgery or significant trauma within 4 weeks before the start of anetumab ravtansine
Had solid organ or bone marrow transplantation
Have LVEF (left ventricular ejection fraction) \<50% at screening
Have QTc \>450 ms or heart rate ≥100 bpm or ≤45 bpm at screening
Poor CYP2D6 metabolizers based on the screening test for genetic polymorphisms in CYP2D6 metabolizing capacity
