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The Effects of Bariatric Surgeries on Glucose Metabolism | Clinical Trials | Clareo Health

RECRUITINGEARLY_PHASE1

The Effects of Bariatric Surgeries on Glucose Metabolism

NCT02823665•The University of Texas Health Science Center at San Antonio

Summary

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Detailed Description

The purpose of this study is to determine the weight-independent effects of gastric bypass surgery and sleeve gastrectomy surgery on islet cell response after meal ingestion as mediated by hormonal and neural components of the gut. It will also address the differences between the two procedures. Such information will be critical for the development of novel approaches for treatment of diabetes as well as improvement of glycemic effects of gastric bypass and sleeve gastrectomy in patients with partial diabetes remission or relapse after complete remission.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
•Asymptomatic individuals with bariatric surgery
•Healthy non-surgical patients with no personal history of diabetes
•Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion Criteria

•Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
•RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
•Healthy non-surgical patients with personal history of diabetes
•For administration of atropine, the following exclusions also apply:
•History of glaucoma
•Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
•Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
•Myasthenia gravis
•Brain pathology
•Enlarged prostate in men

Locations (2)

Texas Diabetes Institute - University Health System

San Antonio, Texas, United States

South Texas Veterans Health Care System

San Antonio, Texas, United States

Key Dates

Start Date

July 1, 2015

Primary Completion Date

August 1, 2026

Completion Date

August 1, 2027

Last Updated

September 9, 2025

Enrollment

200

ESTIMATED participants

Conditions

Post Bariatric SurgeryGastric BypassSleeve GastrectomyHypoglycemia After Gastric Bypass

Interventions

Exendin-(9-39)

DRUG

Atropine

DRUG

Contacts

Marzieh Salehi, MD MS

CONTACT

210-567-6691 salehi@uthscsa.edu

Jennifer Foster, MSN

CONTACT

210-450-8696 fosterj6@uthscsa.edu

Bougie Diameter on Outcomes in Laparoscopic Sleeve Gastrectomy

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Bariatric Sleeve Gastrectomy

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 9, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effects of Bariatric Surgeries on Glucose Metabolism

Inclusion Criteria

Exclusion Criteria

Bougie Diameter on Outcomes in Laparoscopic Sleeve Gastrectomy

Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA

Powered Handle Primary Sleeve Gastrectomy Study

Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy

Paragastric Block for Pain and PONV in Sleeve Gastrectomy

Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in Combination With Paragastric Neural Block