Improving Renal Complications in Adolescents With Type 2 Diabetes Through REsearch Cohort Study (National iCARE Study)

Exclusion Criteria

• •Criteria for Diagnosis of T2D:
• •1. Diagnosis of diabetes will be made according to the Canadian Diabetes Association criteria. There must be 2 abnormal blood glucose tests on different days OR 1 abnormal blood glucose test + symptoms of diabetes:
• •* Fasting plasma glucose of \> 7.0 mmol/L or
• •* Random glucose \> 11.1mmol/L or
• •* 2 hour glucose \> 11.1 mmol/L after a standard oral glucose tolerance test (75g) or
• •* Hemoglobin A1c value ≥ 6.5%
• •2. Distinguishing T2D from type 1 diabetes (T1D) will be based on clinical risk factors including:
• •* Presence of overweight/obesity,
• •* Other evidence of insulin resistance (acanthosis nigricans)
• •* Family history of type 2 diabetes (1st degree relative)
• •* Intrauterine exposure to hyperglycemia,
• •* Family heritage from a high-risk ethnic group (Indigenous, Hispanic, South Asian, Asian or African descent)
• •* Absence of diabetes associated auto-antibodies
• •* HNF-1 alpha heterozygote or homozygote
• •1. Diabetes secondary to medication use or surgery
• •2. Antibodies suggestive of type 1 diabetes
• •3. Current treatment with oral steroids or immunosuppressive agents as they may interfere with cortisol assessment and inflammatory markers
• •4. Ever cancer
• •5. Other chronic illness associated with systemic inflammation (ex. Juvenile rheumatoid arthritis, Crohns disease)
• •6. Patient and or caregiver unable or unwilling to provide voluntary informed assent/consent