Finding studies
Finding studies
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Lead
PATH
With
Primary objectives: 1. Establish a human challenge model of S. sonnei 53G infection using a lyophilized formulation of the challenge strain. 2. Identify a dose of lyophilized S. sonnei 53G that induces the primary outcome in approximately 60% of subjects with no adverse safety concerns. Secondary objectives: 1. Estimate quantitative shedding and basic immunogenicity of the challenge strain. 2. Collect and archive blood and fecal samples for systems biology, microbiome, and other omics-based work to be conducted under a separate research protocol in future studies.
Age
18–49
Sex
ALL
Healthy volunteers
Accepted