Naloxegol Drug Utilization Post Authorisation Safety Study

The overall research questions for this study are: 1) What are the demographic, clinical, and treatment characteristics (including dose) at baseline of patients prescribed naloxegol in real-world practice (including the use of naloxegol in non-indicated populations)? and 2) What are the treatment patterns of naloxegol utilization during follow-up? Primary objectives: 1. To describe the characteristics of patients prescribed naloxegol at time of first prescription (demographics, targeted comorbidities, targeted comedications, provider characteristics, and indication characteristics). 2. To describe any of the following treatment patterns: * Discontinuation of naloxegol (permanently during the observation period) * Switching from naloxegol to other drug(s) potentially used by patients with opioid induced constipation (OIC) * Prescription of other drug(s) potentially used by patients with OIC in the same period when naloxegol is prescribed (augmentation) * Restart in the prescription of naloxegol (after temporary discontinuation or treatment holiday) * Continuous treatment with naloxegol during the study period * Change in dosing Exploratory objective: 1\. To identify predictors of length of naloxegol use