Comparison of PET Amyloid Imaging in Japanese and Western Subjects

Inclusion Criteria

• •1. The subject had at least 6 years of education.
• •2. The subject was of first-order Japanese descent.
• •3. The subject exhibited adequate visual, auditory and communication capabilities, and was willing and able to complete standard tests of cognitive function.
• •4. The subject's general health was adequate to comply with all study procedures, as ascertained by review of their medical history, and laboratory and physical examinations, which was performed within 45 days before the first administration of Flutemetamol F 18 Injection.
• •5. The subject (and the caregiver, if relevant) was/were compliant and had a high probability of completing the study in the opinion of the investigator.
• •6. Women were either surgically sterile (had a documented bilateral oophorectomy and/or documented hysterectomy) or were postmenopausal (cessation of menses for more than 2 years).
• •7. Informed consent was signed and dated by the subject and/or subject's legally acceptable representative, if applicable, in accordance with local regulations.
• •1. The subject was 25 years or older at the time of obtaining informed consent.
• •2. The subject had no evidence of cognitive impairment by medical history.
• •3. The subject had a Mini-Mental State Examination (MMSE) score of =\< 27.
• •4. The subject had a Clinical Dementia Rating (CDR) of 0.
• •5. The subject had an MRI image as part of the screening visit of sufficient diagnostic quality and consistent with normal brain function (details provided in the associated Imaging Manual) for volume of interest (VOI) definition and partial volume correction.
• •1. The subject was 55 years or older at the time of obtaining informed consent.
• •2. The subject met National Institute of Neurological and Communicative Disorders and Stroke; Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for clinical pAD and Diagnostic and Statistical Manual of Mental Disorders (DSM-IV\]), 4th Edition, criteria for AD (DSM-IV criteria, American Psychiatric Association 1994).
• •3. The subject had an MMSE score of 15 to 26 (inclusive) and a CDR of 0.5, 1 or 2.
• •4. The subject had a score of =\< 4 on the Modified Hachinski Ischemic scale.
• •5. The subject had an appropriate caregiver capable of accompanying the subject on all study visits.
• •6. The subject had an MRI image as part of the screening visit consistent with the diagnosis of pAD and of sufficient diagnostic quality (details provided in the associated Imaging Manual) for VOI definition and partial volume correction.
• •1. The subject was 55 years or older at the time of obtaining informed consent.
• •2. The subject met Petersen criteria for aMCI.
• •3. The subject had an MMSE score of 27 to 30 (inclusive) and a CDR of 0 to 0.5.
• •4. The subject had a score of =\< 4 on the Modified Hachinski Ischemic Scale.
• •5. The subject had an appropriate caregiver/companion capable of accompanying the subject on all study visits if necessary and applicable according to local regulations.
• •6. The subject had an MRI image as part of the screening visit consistent with the diagnosis of aMCI and of sufficient diagnostic quality (details provided in Imaging Manual) for VOI definition and partial volume correction.