The Role of Molecules in Blood Cells for Diagnosing Bipolar Disorders

Inclusion Criteria

• •For inclusion in this study, subjects must meet all of the following criteria:
• •1. Able to provide informed consent;
• •2. Male or female, at least 18 years of age;
• •3. Physically healthy
• •4. No current and/or lifetime psychiatric disorder assessed with the MINI for Diagnostic and Statistical Manual-5 (DSM-5);
• •5. Willing to have blood draw.
• •For inclusion in this study, subjects must meet all of the following criteria:
• •1. Able to provide informed consent;
• •2. Male or female, at least 18 years of age;
• •3. Meets current DSM-5 criteria for bipolar type I (BPI) or bipolar type II (BP II) disorder as assessed by the MINI.
• •4. Depression severity should be measured with Montgomery-Asberg Depression Rating Scale (MADRS). A MADRS total score ≥ 20 is required at Screening Visit/Baseline Evaluation.
• •5. Has experienced impairment as documented by a score consistent with moderate impairment (4 or more on at least one of the three subscales of the Sheehan Disability Scale (SDS), which includes an assessment of work-life, family-life, and social life (no/mild impairment 0-3, moderate impairment 4-6, severe impairment 7-10)
• •6. Have not taken any psychotropic medications within the past 4 weeks;
• •7. Willing to have blood draw.