MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement

Exclusion Criteria

• •eGFR \<45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009), and in particular severe chronic renal failure defined as serum creatinine \> 250 umol/l;
• •Patients in unstable clinical conditions;
• •Known secondary hypertension;
• •Orthostatic hypotension (SBP fall \> 20 mmHg on standing);
• •Dementia (clinical diagnosis);
• •Hepatic disease as determined by either AST or ALT values \> 2 times the upper limit of normal
• •History of gastrointestinal surgery or disorders which could interfere with drug absorption
• •Known allergy or contraindications to one of the drugs to be administered in the study
• •History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years
• •History of clinically significant autoimmune disorders such as systemic lupus erythematosus.
• •History of drug or alcohol abuse within the last 5 years
• •History of non-compliance to medical regimens and/or patients who are considered potentially unreliable
• •Inability or unwillingness to give free informed consent
• •Pregnancy or planned pregnancy during study period.