Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers

Exclusion Criteria

• •Dedifferentiated chordomas, chondrosarcoma
• •History of cancer (except cutaneous basocellular epithelioma or epithelioma of the uterine cervix) having recurred in the 5 years preceding entry in the trial and no relapse in the last 3 years
• •Metastatic patient
• •History of brain radiation therapy, or base of the skull or spinal segments to be treated
• •Contraindications to radiotherapy
• •Contraindications to PET/CT examinations \[18F\] Fluorodexoxyglucose (FDG) and \[18\]FAZA
• •Associated pathology likely to prevent the patient from receiving treatment,
• •Incompatible treatment with the inclusion in the study (oxygen therapy, EPO, anti-vascular treatments, anti-angiogenic treatments)
• •Patient already included in another therapeutic trial with an experimental medication,
• •Patient currently nursing,
• •Persons deprived of their liberty, or under guardianship,
• •Impossibility of undergoing the trial's medical follow-up for geographical, social or psychological reasons.