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Keep this study
Lead
Maastricht University Medical Center
The activity in the food reward-circuitry of the brain in patients suffering from cachexia induced by cancer (lung cancer or pancreatic cancer) or chronic disease (chronic obstructive pulmonary disease) will be analysed by using functional magnetic resonance imaging. In addition, the role of the peripheral satiety hormones will be evaluated.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
For cachectic patients: weight loss exceeds 5% of total body weight over the past 6 months, or \>2% when body mass index is \<20 kg/m2
For non-cachectic patients: no weight loss of ≥5% during the last 6 months
Non-small cell lung cancer or gastro-intestinal cancer, pathology proven or diagnosis of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria
You may not be if
Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; Pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up)
Psychiatric or other disorders likely to impact on informed consent
Presence of brain metastasis (screening is not mandatory)
Medical history of cerebrovascular accident, brain tumour, brain metastasis
Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy
Memory problems
Current use of tube feeding or parental nutrition
Patients with an active second malignancy
Patients unable to lie still for 2 hours
Unable to complete the cognitive task
Pre-existing swallowing difficulties
Allergy to gluten-, milk- or wheat products
Self-reported hyperthyroidism
Self-reported diabetes mellitus
Current use of appetite stimulant medications
Clareo Health | Food Reward in Cachexia Induced by Acute or Chronic Disease
