Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

Exclusion Criteria

• •1. prior chemotherapy or radiotherapy for other malignancies
• •2. pre-treatment of Hodgkin's lymphoma (except for steroid pre-phase to a maximum of 7-10 days for emergency treatment of a large mediastinal tumour).
• •3. diagnosis of lymphocyte-predominant Hodgkin's lymphoma
• •4. other (simultaneous) malignancies
• •5. contraindication or known hypersensitivity to study drugs
• •6. severe concomitant diseases (e.g. immune deficiency syndrome)
• •7. known HIV-positivity
• •8. residence outside the participating countries where long term follow-up cannot be guaranteed
• •9. pregnancy and / or lactation
• •10. patients who are sexually active and are unwilling to use adequate contraception during therapy and for one month after last trial treatment
• •11. current or recent (within 30 days prior to date of written informed consent) treatment with another investigational drug or participation in another interventional clinical trial