Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

Exclusion Criteria

• •pregnant or breastfeeding
• •significant unstable medical/psychiatric or substance use disorders, or medically/psychiatrically at risk in the judgment of the study physician or principal investigator (PI)
• •positive urine screen for cocaine, opiates, methadone, benzodiazepines, barbiturates, amphetamines, methamphetamines, or PCP (NOTES: THC will be tested but will not be an exclusionary criterion; participants with valid prescriptions for opiates, benzodiazepines, barbiturates, amphetamines or methadone will not be excluded; participants failing the toxicology screen will be allowed to re-screen once)
• •breath alcohol level \> 0.01 (one re-screen allowed)
• •binge alcohol drinking (4/5 \[female/male\] drinks per day more than 9 days in the past month)
• •systolic/diastolic blood pressure (BP) greater than or equal to 160/100, or below 90/50 (one re-screen allowed)
• •heart rate greater than or equal to 105 beats per minute (bpm), or below 45 bpm (one re-screen allowed)
• •ever used reduced nicotine cigarettes
• •smoke 'roll your own' cigarettes exclusively
• •used smoking cessation medications within the past three months
• •are currently enrolled in a smoking cessation program
• •actively trying to quit
• •used other tobacco products (including e-cigarettes more than 9 days in the past month
• •currently taking the following medications: Phenytoin \[Brand Name: Dilantin\]; Carbamazepine \[Brand Name: Tegretol, Carbatrol, Equetro, Epitol\]; Oxcarbazepine \[Brand Name: Trileptal\]; Primidone \[Brand Name: Mysoline\]; Phenobarbital; Bendamustine (Treanda); Clopidogrel (Plavix); Clozapine (Clozaril, FazaClo); Erlotinib (Tarceva); Flecainide (Tambocor); Fluvoxamine (Luvox); Irinotecan (Camptosar); Olanzapine (Zyprexa); Ropinirole (Requip); Tacrine (Cognex); Theophylline (Theo Dur, etc.).