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Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study | Clinical Trials | Clareo Health

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Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study

NCT02780973•University of Göttingen

View on ClinicalTrials.gov

Summary

Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion. Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured. The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.

Eligibility

Age

20 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy probands aged between 20 and 40 years who are able to give written consent
•Smoking
•Hyposalivation / xerostomia (unstimulated saliva \< 0.3 mL/min, stimulated saliva \< 0.7 mL/min)
•Intake of any medication (except contraceptives in women)
•Pregnant or lactating women
•Known allergies to substances used in the study
•Orthodontic treatment or malfunction which doesn't allow to wear an intraoral device

Locations (1)

University Medical Center Göttingen, Dept. of Preventive Dentistry, Periodontology and Cariology

Göttingen, Lower Saxony, Germany

Key Dates

Start Date

February 7, 2017

Primary Completion Date

January 18, 2018

Completion Date

January 18, 2018

Last Updated

February 14, 2024

Enrollment

ACTUAL participants

Conditions

Dental Erosion

Interventions

Wearing of an intraoral device with bovine tooth samples

OTHER

Effect of Smoking on Saliva Composition and the Development of Dental Erosion

NCT04208802

Dental Erosion

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 14, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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