Vaccine Therapy in Preventing Cancer Recurrence in Patients With Non-Metastatic, Node Positive, HER2 Negative Breast Cancer That is in Remission

Patients with non-metastatic, node positive, HER2 negative breast cancer, confirmed by pathology report, who are in remission and defined as having no evidence of disease (NED); HER2 negative is defined as

* 0-1+ HER2 expression by immunohistochemistry (IHC) OR

* Fluorescence in situ hybridization (FISH) negative OR

* HER2 2+ and FISH negative

Patients must be at least 28 days post cytotoxic chemotherapy, radiotherapy, monoclonal antibody and/or other biologic therapy, prior to enrollment; patients on bisphosphonates, denosumab, and/or endocrine therapy administered during the study are eligible and may continue throughout duration of study

Patients must be at least 28 days post systemic steroids prior to enrollment

Patients must have Eastern Cooperative Oncology Group (ECOG) performance status score of =\< 2

White blood cell (WBC) \>= 3000/mm\^3

Hemoglobin (Hgb) \>= 10 g/dl

Lymphocyte count \>= 800/mm\^3

Platelet count \>= 75,000/mm\^3

Serum creatinine =\< 2.0 mg/dl or creatinine clearance \> 60 ml/min

Total bilirubin =\< 1.5 mg/dl

Aspartate aminotransferase (AST)/Serum glutamic oxaloacetic transaminase (SGOT) =\< 2 times upper limit of normal (ULN)

Patients must have recovered from major infections and/or surgical procedures, and in the opinion of the investigator, not have any significant active concurrent medical illnesses precluding protocol treatment

The effects of WOKVAC on the developing human fetus are unknown. For this reason, patients who are having sex that can lead to pregnancy must agree to use adequate contraception (hormonal, barrier method of birth control, or abstinence) for the duration of study participation; should a woman become pregnant while participating in the study, she should inform her study doctor immediately and will not receive any more study treatment

Left ventricular ejection fraction (LVEF) results must be \>= lower limit of normal (LLN) for institution performing based on results from the multi-gated acquisition (MUGA) or echocardiogram (ECHO) done at baseline

Willing to not undergo any elective surgical procedure with general anesthesia or conscious sedation through the 1 month post-vaccination visit

Ability to understand and the willingness to sign a written informed consent document

What this study is about