PFO meet one of the following conditions:RLS in rest documented by cTTE or cTCD,combine with ASA,the primary patition mobility≥6.5mm,the diameter of PFO≥4mm, combine with Eustachian Valve or Chiari net.
age 18-60
else:independent in daily activities,to comply with complete follow-up experiment design
You may not be if
contraindication to antiplatelet or anticoagulant
inferior vena cava or pelvic vein thrombogenesis leading to complete obstruction,systemic or local infection,septicemia,heart lumen thrombosis
pregnancy
combine with pulmonary hypertension or PFO made for a particular channel
