Reduced Appetite in Crohn's Disease: The Role of the Brain in the Control of Food Intake

Exclusion Criteria

• •1. Malignant disease
• •2. BMI \<18 and \>35
• •3. Significant cardiovascular or respiratory disease
• •4. Diabetes mellitus
• •5. Current Infection
• •6. Neurological or cognitive impairment; significant physical disability
• •7. Significant hepatic disease or renal failure
• •9. Subjects currently participating in (or in the last three months) any other research project
• •10. pregnancy or breastfeeding or
• •11. if MRI is contraindicated (e.g. pacemaker).
• •12. Severe Crohn's disease where a delay in a change in medical treatment for 23 weeks would not be clinically advisable.