A Study in Preterm Neonates With Respiratory Distress Syndrome (RDS) Comparing CUROSURF® Administration Through Less Invasive Surfactant Administration (LISA) and Conventional Administration

Exclusion Criteria

• •1. Need for immediate endotracheal intubation for cardiopulmonary resuscitation or insufficient respiratory drive
• •2. Use of nasal high frequency oscillatory ventilation (nHFOV) prior to study entry
• •3. Use of surfactant prior to study entry and need for intratracheal administration of any other treatment (e.g. nitric oxide)
• •4. Known genetic or chromosomal disorders, major congenital anomalies (congenital heart diseases, myelomeningocele etc)
• •5. Mothers with prolonged rupture of the membranes (\> 21 days duration)
• •6. Presence of air leaks if identified and known prior to study entry
• •7. Evidence of severe birth asphyxia (e.g. continued need for resuscitation at 10 minutes after birth, altered neurological state, or neonatal encephalopathy)
• •8. Neonatal seizures prior to study entry
• •9. Any condition that, in the opinion of the Investigator, would place the neonate at undue risk
• •10. Participation in another clinical trial of any medicinal product, placebo, experimental medical device, or biological substance conducted under the provisions of a protocol on the same therapeutic target.