A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent GBM

Inclusion Criteria

• •1. Karnofsky Performance Status (KPS) ≥ 60%.
• •2. Life expectancy ≥ 3 months.
• •3. Pathologically documented, and definitively diagnosed recurrent World Health Organization (WHO) Grade IV astrocytoma (GBM).
• •4. Participant must have archived tumor tissue available from initial diagnosis or subsequent relapse(s) of Grade IV GBM for submission for central review at Investigational sites local laboratories.
• •5. Recurrence or progression of disease (confirmed by MRI and measurable by RANO criteria) following receipt of standard of care therapy, which includes maximum safe surgical resection, standard adjuvant radiation/temozolomide treatment. Participants must have completed at least 21 days of temozolomide treatment in combination with radiation therapy to be considered to have received standard of care therapy.
• •6. Participant has received no more than 1 other therapeutic regimen other than those listed above in (5).
• •7. Participant may be receiving steroid therapy at time of enrollment (stable dose of ≤ 4 mg/day of dexamethasone or steroid equivalent).
• •8. Ability to undergo MRI evaluation.
• •9. Participant has ≥ 1 site of bi-dimensionally measurable disease measured using contrast enhanced MRI.
• •10. Hematological function:
• •* White blood cell count (WBC) ≥ 3.0 x 109/L
• •* Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
• •* Platelet count ≥ 100 x 109/L
• •* Hemoglobin \> 9 g/dL
• •* Prothrombin time (PT) or partial thromboplastin time (PTT) \< 1.5 x upper limit of normal (ULN)
• •* International normalized ratio (INR) \< 1.5 x ULN
• •11. Renal function:
• •* Blood urea nitrogen (BUN) \< 30 mg/dL
• •* Creatinine serum levels ≤ 1.5 x ULN
• •* Or creatinine clearance ≥ 60 mL/minute for subjects with serum creatinine outside the normal range (calculated using the Cockcroft-Gault equation).
• •12. Hepatic function:
• •* Aspartate aminotransferase (AST) \< 2.5 x ULN (3 x ULN for subjects on chronic anticonvulsive therapies known to increase transaminases).
• •* Alanine aminotransferase (ALT) \< 2.5 x ULN (3 x ULN for subjects on chronic anticonvulsive therapies known to increase transaminases).
• •* Alkaline phosphatase (ALP) \< 2.5 x ULN (3 x ULN for subjects on chronic anticonvulsive therapies).
• •* Total bilirubin ≤ 1 x ULN (unless elevated due to Gilbert's syndrome or extrahepatic source as denoted by increased indirect bilirubin fraction. Subjects with ≥1 x ULN will be tested for direct bilirubin fraction so that the indirect fraction can be calculated).
• •13. Adequate cardiac function with left ventricular ejection fraction (LVEF) ≥ 55% at baseline.
• •14. Serum phosphate levels that are within normal limits (2.4 - 4.1 milligrams per deciliter mg/dL) at baseline.
• •15. Subject meets the reproductive criteria as follows:
• •* Female subjects who are of non-reproductive potential (ie, post menopausal by history - no menses for ≥ 1 year and follicle-stimulating hormone (FSH) level consistent with post-menopausal status; OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral oophorectomy).
• •* Female subjects of childbearing potential must have a negative serum pregnancy test within 7 days prior to the 1st dose, if more than 7 days prior, a urine pregnancy test must be performed before the 1st dose. The female subject must be willing to use highly effective methods of birth control during the period of therapy and for 6 months following the last study IP administration. Highly effective methods of birth control include sexual abstinence, hormonal birth control, or intrauterine device (women), vasectomy or a condom with spermicide (men) in combination with barrier methods.
• •* Male subjects who are willing to use highly effective methods of birth control during the period of therapy and for 6 months following the last IP administration.
• •* All study subjects must be willing to ensure that corresponding sexual partners practice these same methods of highly effective birth control for the same duration.