TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

Exclusion Criteria

• •1. Meet criteria for psychotic disorders, e.g. schizophrenia/ schizoaffective disorder.
• •2. Women who are pregnant or are breast-feeding (because the medical risk of using ketamine during pregnancy and breast-feeding are unknown);
• •3. Serious, unstable medical illnesses such as hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease (including obstructive sleep apnea, history of difficulty with airway management during previous anesthetics, ischemic heart disease and uncontrolled hypertension, and history of severe head injury);
• •4. Clinically significant abnormal findings of laboratory parameters, or physical examination;
• •5. Patients with uncorrected hypothyroidism or hyperthyroidism;
• •6. Histories of mental retardation
• •7. History of one or more seizures without a clear and resolved etiology;
• •8. Drug or alcohol abuse or dependence within the preceding 3 months: phencyclidine (PCP) is especially important in this context because of its resemblance with ketamine not only in structure but also its pharmacodynamic effects on NMDA receptors.
• •9. Previous recreational use of ketamine;
• •10. Diagnosis of schizotypal or antisocial personality disorder (since these are known to reduce the possibility of study completion; other Axis II diagnoses will be allowed).