An Efficacy and Safety Study of LYC-30937-EC in Subjects With Active Ulcerative Colitis

Exclusion Criteria

• •History of Crohn's disease (CD) or indeterminate colitis or the presence or history of fistula consistent with CD.
• •Presence of colon polyps.
• •Severe extensive disease that in the investigators discretion is likely to require colonic surgery during the 8 week double-blind portion of the trial (eg, fulminant colitis, toxic megacolon, bowel perforation, evidence of acute abdomen).
• •History of alcohol or drug abuse within 1 year of randomization.
• •History of cancer including solid tumors and hematological malignancies (except basal cell and in situ squamous cell carcinomas of the skin that have been adequately treated with no recurrence for ≥ 1 year prior to screening.
• •History or currently active primary or secondary immunodeficiency.
• •Clinically relevant hepatic, neurologic, pulmonary, ophthalmological, gastrointestinal, endocrine, psychiatric, or other major systemic disease making implementation of the study difficult or that would put the subject at risk by participating in the study
• •Positive test for Clostridium difficile or positive stool culture for enteric pathogens or presence of ova or parasites at screening.
• •Liver function tests \> 1.5 x upper limit of normal (ULN) or direct bilirubin \> 1.5 x ULN
• •Hemoglobin \< 8.5 g/dl
• •Neutrophils \< 1500/mm3
• •White blood cell (WBC) count \< 3000/mm3
• •Platelets \< 80000 mm3
• •International normalized ratio (INR) \> 1.5
• •Treatment with an immunosuppressant agent within 8 weeks of screening.
• •Previous exposure to ≥ 2 approved or investigational biologic agents to treat UC.
• •History of UC treatment with a biologic agent within 12 weeks of screening.
• •Treatment with rectal steroids within 2 weeks of screening.
• •Treatment with an investigational agent within 30 days of screening.