An interventional, prospective, multi center pilot study to assess the clinical relevance of CgA levels in patients with PNET as performed in current clinical practice.
There will be a measurement of CgA levels at baseline (preoperative measures after consent) and afterwards, in 3, 6, 12, and 24 months after resection. Immunoradiometric assay (IRMA, normal values: \< 100 ng/mL) will be used.
The collection of blood samples will proceed as detailed below:
Extraction of samples for serum collection:
7 ml of blood without anticoagulants will be allowed to sit for 30 min at room temperature before the serum is separated by centrifugation (3500 rpm). The serum will be stored at -20ºC
Assessments: Baseline (preoperative measures after consent), 3,6, 12, and 24 months
Clinical parameters: weight, height, performance status, vital signs including blood pressure, clinical signs and symptoms, survival data
Blood biochemical parameters: Sodium, potassium, calcium, glucose, urea, creatinina, bilirubin, alkaline phosphatase, aspartate transaminase (AST), and alanine transaminase (ALT).
Computed tomography (CT) : preoperative condition, and 3,6,12,24 months after resection.
