Loading clinical trials...

Clinical Study of Regeneration on Larynx Soft Tissue Guided by Functional Collagen Scaffold | Clinical Trials | Clareo Health

COMPLETEDPHASE1

Clinical Study of Regeneration on Larynx Soft Tissue Guided by Functional Collagen Scaffold

The Safety and Efficacy Assessment of Functional Collagen Scaffold Transplantation for Larynx Soft Tissue Regeneration

NCT02754284•Chinese Academy of Sciences

View on ClinicalTrials.gov

Summary

This study is carried out to explore the short-term and long-term efficacy of the functional collagen scaffold in guiding laryngeal soft tissue regeneration.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Age of 18-65 years old, male or female
•2. Severe unilateral vocal cord injury and poor closure of the glottis
•3. Disease course was more than 1 year
•4. At least two GRBAS scores reach 2 points or more
•5. The subjects have read and fully understood the research notes, signed informed consent

Exclusion Criteria

•1. Over speaking professionals, such as teachers, shop assistants.
•2. With vital organ dysfunction, such as heart, lung, liver or kidney.
•3. Pregnant or lactating women, or in preconception period.
•4. Allergic to various drugs.
•5. Difficult to be followed-up or cooperate long-termly.
•6. Participated in other clinical trials in the last 3 months.
•7. With progressive severe disease.
•8. Alcoholics or drug addicts.
•9. Unable to execute clinical study protocol due to severe mental disorders or lingual barriers
•10. With inevitable circumstances of voice damage.
+1 more criteria

Locations (1)

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Beijing, China

Key Dates

Start Date

December 1, 2015

Primary Completion Date

June 1, 2020

Completion Date

June 1, 2020

Last Updated

January 5, 2021

Enrollment

ACTUAL participants

Conditions

Vocal Cord Dysfunction

Interventions

Autologous fat transplantation

BIOLOGICAL

Functional collagen scaffold transplantation

BIOLOGICAL

Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion

NCT07420530

Exercise-Induced Vocal Cord DysfunctionParadoxical Vocal Fold Motion+1 more

View study

COMPLETED

Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma

NCT05246930

Breathing, MouthLung Function Decreased+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 5, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Clinical Study of Regeneration on Larynx Soft Tissue Guided by Functional Collagen Scaffold

Inclusion Criteria

Exclusion Criteria

Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion

Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma

Is Laryngeal Ultrasound Useful in the Assessment for ILO? A Protocol for a Two-stage Exploratory Pilot Study

The Role of Vocal Rest After Removal of Benign Lesions From Vocal Cord

Treatment of Paradoxical Vocal Fold Motion Disorder (PVFMD) With a Form of Respiratory Retraining Technique