[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica

Inclusion Criteria

• •General:
• •At least 18 years of age
• •Either male or female
• •Sciatica:
• •History of pain shooting down a leg below the knee, to the foot or toes
• •Visual analog scale (VAS) at enrollment of \>4 with leg pain greater in intensity than the back pain
• •Focal disc herniation on MRI correlating with radicular symptoms defined as pain or paresthesias into the leg.
• •Examination with correlating radicular signs defined as any of the following:
• •pain reproduction with straight-leg-raising (pain shooting down the leg with less than 60 degrees elevation)
• •radicular pattern sensory changes (such as numbness or paresthesias) in the same area as pain
• •signs of radiculopathy (weakened hallux extension and/or Achilles tendon reflex)
• •CRPS:
• •Disease duration of 6 months or longer
• •Continuing pain, which is disproportionate to any inciting event
• •Must report at least one symptom in three of the four following categories:
• •1. Sensory: Reports of hyperesthesia and/or allodynia
• •2. Vasomotor: Reports of temperature asymmetry and/or skin color changes and/or skin color asymmetry
• •3. Sudomotor/Edema: Reports of edema and/or sweating changes and/or sweating asymmetry
• •4. Motor/Trophic: Reports of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin)
• •Must display at least one sign at time of evaluation In two or more of the following categories:
• •1. Sensory: Evidence of hyperalgesia (to pinprick) and/or allodynia (to light touch and/or temperature sensation and/or deep somatic pressure and/or joint movement)
• •2. Vasomotor: Evidence of temperature asymmetry ( \>1°C) and/or skin color changes and/or asymmetry
• •3. Sudomotor/Edema: Evidence of edema and/or sweating changes and/or sweating asymmetry
• •4. Motor/Trophic: Evidence of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin)
• •There is no other diagnosis that better explains the signs and symptoms
• •For research purposes, diagnostic decision rule will be at least one symptom in all four symptom categories and at least one sign (observed at evaluation) in two or more sign categories.