Assessment of Bone Biomarkers for TKI Response in RCC With Bone Metastases, HRQoL and Comparison of Imaging Techniques

Exclusion Criteria

• •Pregnancy, breastfeeding or fertile patients who do not use adequate contraceptive methods
• •Non-clear cell histology
• •Non irradiated brains metastases
• •Symptomatic brain metastases
• •Inability to undergo any of the medical tests of the study
• •A history of breast cancer or melanoma. Other tumors are accepted as long as the patients has been for at least 5 years free of disease
• •Synchronic diagnosis of another neoplasm
• •Presence of an active infection
• •Any decompensated disease or metabolic disorder
• •Cardiac events or pulmonary embolism in the 12 months previous to inclusion