Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease

Exclusion Criteria

• •History of seizure disorder, including febrile seizures;
• •Neurological disorder including PD, stroke, traumatic brain injury, fainting spells or syncope of unknown cause(s);
• •Major or unstable medical illness;
• •Pacemakers, neurostimulators, tattoos or metal foreign bodies in the head area (dental fillings are allowed);
• •Untreated depression, or score of \>20 on Beck Depression Inventory II;
• •Taking any of the following medications within the six weeks prior to the start of the study: imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, theophylline, calcium channel blockers, beta blockers, tadalafil, vardenafil, avanafil, and sildenafil;
• •Diagnosis of dementia, or Montreal Cognitive Assessment (MoCA) \<20;
• •Any clinically significant abnormality on vital signs
• •Cardiopulmonary limitations: untreated high blood pressure, history of heart insufficiency (class II-III), coronary vascular disease, angina, arrhythmia, dyspnea on exertion and asthma