Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

TPS of ≥5 for both nostrils with presence on endoscopy of nasal polyps of grade ≥2 in each nostril according to the polyp grading scale
History of sinusitis symptoms
SNOT-22 ≥30
No clinically significant Screening 12-lead ECG, vital sign, hematology, chemistry, or urinalysis findings

Use of systemic corticosteroids within 6 weeks of screening
Chronic use of antibiotic therapy within 3 months prior to Screening
Nasal surgery (including polypectomy) within 6 months prior to Screening
Use of investigational drugs or participation in another clinical trial within 30 days prior to Screening or 5 half-lives, whichever is longer

Study to Evaluate Multiple Doses in Patients With Nasal Polyposis