Efficacy and Safety Study of Squalamine Ophthalmic Solution in Subjects With Neovascular AMD

Phase 3 Study of the Efficacy and Safety of Squalamine Lactate Ophthalmic Solution 0.2% Twice Daily in Subjects with Neovascular Age-Related Macular Degeneration Methodology: Phase III, multicenter, randomized, double-masked, placebo-controlled study conducted over 9 months (Screening/Baseline to Week 36): Patients will be randomly assigned to one of 2 treatment groups in a 1:1 ratio: * Squalamine lactate ophthalmic solution, 0.2% BID + ranibizumab every 4 weeks * Placebo ophthalmic solution BID + monthly ranibizumab every 4 weeks